The Hilton St. Petersburg Bayfront hotel is located in the heart of the waterfront district in downtown St. Petersburg, which blends historic charm and a rich past with modern luxuries and amenities. The hotel is near the area's most popular attractions, including the Salvador Dalí Museum, the Morean Arts Center, Mahaffey Theater, Al Lang Stadium, Tropicana Field and a variety of pristine Florida beaches. It is also close to major airports, with about 22 miles away from the Tampa International Airport, and 15 miles away from St Petersburg-Clearwater International Airport.

The hotel provides a large selection of stylish and functional meeting rooms. It has more than 30,000 sq. ft. of flexible event venues, including 20 break out areas and 7,000 sq. ft. ballroom , as well as full catering services and onsite A/V support. Also, the hotel offers various choices of guest rooms, and each room is furnished with designer furniture and business facilities. A variety of specialized services and amenities provided for the guests include fitness facilities, pool, jogging path along the bay, etc.